Hong Zhao University of Illinois at Urbana-Champaign Ph.D. Theoretical and Applied Mechanics, 2006 M.S. Mathematics, 2005 M.S. Mechanical Engineering, 2002 University of Science and Technology of China B.S. Theoretical and Applied Mechanics, 2000 |
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My research focuses on the flow physics in microcirculation, which is
dominated by the cell--cell and cell--wall interactions. One problem of our
particular interest is the effect of red cells on the margination of
platelets, which is of critical importance for proper blood clotting. We have
developed a highly efficient boundary integral equation method that fully
resolves the flow structure interactions between deformable red cells,
platelets that are modeled as rigid discoids, and wall boundaries. The
simulation reproduces the near wall platelet concentration as observed in
experiments.

Another area of my research is the rheology of vesicles, which have attracted
much interests because of the simplicity in their physical properties and the
their potential usage for drug delivery. A vesicle is essentially a lipid
bilayer that itself behaves as a two-dimensional incompressible fluid but
shows bending resistance. Using numerical simulations based on Stokes flow
boundary integral equations, we obtain flow regime diagram of a single vesicle
in unbounded shear flow that quantitatively agrees with high-order
perturbation analysis. We currently focus on studying the rheology of
vesicles that are confined by wall boundaries as in microfluidic devices, as
well as the effect of vesicle--vesicle interactions.

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